- 作者: Jasmin Shah,* M. Rasul Jan and Suraya Manzoor
- 作者服務機構: Institute of Chemical Sciences, University of Peshawar, N.W.F.P., Pakistan
- 中文摘要: Two simple and sensitive extractive spectrophotometric methods have been described for the analysis of clarithromycin in pure form and in pharmaceutical formulations. The methods involved formation of yellow colored chloroform extractable ion-association complexes of clarithromycin with bromothymol blue (BTB) and cresol red (CR) in buffered aqueous solution at pH 4. The extracted complexes showed maximum absorbance at 410 and 415 nm for BTB and CR, respectively. Beer’s law is obeyed in the concentration ranges 0.1-20μg mL-1 and 2.0-20μg mL-1 of clarithromycin with molar absorptivity of 2.01 104 and 4.378 103 for BTB and CR, respectively. The composition ratio of the ion-association complex was clarithromycin: BTB and CR = 1:1 as established by Job’s method. The methods have been applied to the determination of drug in commercial formulations. The results of analysis were validated statistically and through recovery studies.
- 英文摘要: --
- 中文關鍵字: Clarithromycin; Bromothymol blue; Cresol red; Spectrophotometric; Ion-association complexes.
- 英文關鍵字: --