- 作者: Ming-Jer Young, Kai-Cheng Hsu, Tony Eight Lin, Wen-Chang Chang and Jan-Jong Hung
- 作者服務機構: 1. Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, 701, Taiwan 2. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 3. Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 4. Biomedical Commercialization Center, Taipei Medical University, Taipei, Taiwan 5. Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan 6. The Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan
- 中文摘要:
- 英文摘要:
Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such as cancer. Two types of enzymes, namely, E1/E2/E3 ligases and deubiquitinases, are responsible for controlling protein ubiquitination. The ubiquitin-specific peptidases (USPs) are the main members of the deubiquitinase family. Many studies have addressed the roles of USPs in various diseases. An increasing number of studies have indicated that USPs are critical for cancer progression, and some USPs have been used as targets to develop inhibitors for cancer prevention. Herein we collect and organize most of the recent studies on the roles of USPs in cancer progression and discuss the development of USP inhibitors for cancer therapy in the future. - 中文關鍵字:
- 英文關鍵字: Ubiquitination, Deubiquitinases, Ubiquitin-specific peptidases, Cancer