- 作者: --
- 作者服務機構: Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt
- 中文摘要: A convenient synthesis of some novel 6-amino-4-aryl-1-phenyl-3-pyridin-4-yl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles (3a,b) and 5-chloro-1-phenyl-3-pyridin-4-yl-1H-pyrazole-4-carbaldehyde (4) is described. Compound 4 was obtained by the reaction of 2-phenyl-5-pyridin-4-yl-2,4-dihydropyrazol-3-one (1) with dimethylformamide and phosphorus oxychloride under Vilsmeier-Haack reaction conditions. Compound 4 was subjected to react with different reagents such as hippuric acid, sodium azide and aromatic ketones to afford 4-(5-chloro-1-phenyl-3-pyridin-4-yl-1H-pyrazolo-4-ylmethylene)-2-phenyl-4H-oxazol-5-one (5), 5-azido-1-phenyl-3-pyridin-4-yl-1H-pyrazol-4-carbaldehyde (8) and 1-aryl-3-(5-chloro-1-phenyl-3-pyridin-4-yl-1H-pyrazol-4-yl)propenones (12a,b), respectively. The latter compounds were also prepared via Michael reaction by treatment of compound 1 with some different chalcones.
- 英文摘要: --
- 中文關鍵字: 2,4-Dihydropyrazol-3-one; Dimethylformamide; Vilsmeier-Haack reaction; Phase-transfer catalysis (PTC); Knoevenagel condensation; Michael reaction; Chalcones.
- 英文關鍵字: --