• 作者： 于迺文; 陳淑真; 許織雲
• 作者服務機構： 國防醫學院生物形態學系
• 中文摘要： 利用組織化學技術顯示牛蛙蝌蚪在生長變態過程中，腎上腺皮質內 △ -3β-羥基類固醇去氫
  ?之分佈情況，並用掃描顯微分光儀配台電腦測量其透光度之百分比，表示該?活性之消長，藉
  以闡明腎上腺皮質功能之發育。
  結果獲知，該?之活性在蝌蚪之發育期間顯示逐漸增長之趨勢；自外鰓期開始出現，唯其量
  甚微。至後肢芽期由顆粒之分佈及透光度之百分比顯示該?之活性迅速增加。其後變態初期變化
  甚少，趨於穩定。變態後期有增加之趨向，至變態高?時該?之活性有突破性增加。變蛙後又趨
  下降。
  七
• 英文摘要： Histochemical analysis of △ -3β-hydroxy-steroid dehydrogenase (△ -3β-HSD) in theadrenal cortex was investigated at variousdevelopmental stages of Rana catesbeiana. Ascanning microscope spectrophotometer togetherwith a minicomputer were used to evaluate thepercentage of transmittanc of the reaction pro-duct of the enzyme activity, in order to eva-luate the changes of △ -3β-HSD activity andthe functional development of adrenal cortex. The result shows that the activity of △ -3β-HSD increases gradually during the develop-mental stages. It begins to appear weakly incortical cells at Shumway stage 23, then rapidlyincreases with the differentiation of the adrenalcortex. A low increasing activity is fol-lowed at premetamorphic and prometamorphicstages. After then, it again increases veryrapidly to reach a peak at the metamorphicclimax. The strong enzyme activity at thisstage seems to be important in regulating me-tamorphosis of anuran tadpoles. However, atthe young frog stage, the activity drops.
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