• 作者： 余幸司; 陳國熏; 許漢銘; 高照星; 張基隆; 余家利
• 作者服務機構： 高雄醫學院皮膚科; 高雄醫學院生化學科; 台北榮民總醫院免疫風濕科
• 中文摘要： 以組織免疫化學法及形態測定法探討烏腳病地區皮膚砷癌病人（包括波文氏病14位，基底細胞癌6位，鱗狀細胞癌6位），皮膚關連淋巴組織之變動。表皮蘭格罕氏細胞數目由正常表皮、砷癌周邊正常外觀皮膚、皮膚砷癌依序遞減，其形態亦逐漸喪失原有之細胞突起。此種蘭格罕氏細胞之漸進性破壞示唆著皮膚砷癌癌化程度之進行。砷癌周圍之浸潤細胞之多數為T淋巴細胞，浸潤細胞數與蘭格罕氏細胞數不呈正比關係。鱗狀細胞癌周圍之T淋巴細胞浸潤遠較波文氏病及基底細胞癌為少。波文氏病及鱗狀細胞癌周圍浸潤細胞之helper/suppressor T細胞比較基底細胞癌者為高，此可能是因helper T細胞在前兩種砷癌呈現選擇性的匯集所致。
• 英文摘要： We investigated the skin-associated lymphoid tissue in arsenical skin cancers, including 14 Bowen'sdisease, 6 basal cell carcinoma and 6 squamous cell carcinoma patients from an endemic area by im-munohistochemical and morphometric methods. There was a progressive decrease of Langerhans cells in theorder of normal skin, normal appearing edge and arsenical cancers. A disruption of the uniform Langerhanscell dendrites was also noticed. The Langerhans cell density in arsenical tumors did not correlate with theperitumoral infiltrates. The prominent infiltrated cells in the peritumoral area had T cell markers. Thenumber of peritumoral T lymphocytes in squamous cell carcinoma was significantly less than that of Bowen'sdisease and basal cell carcinoma. Peritumoral mononuclear infiltrates in Bowen's disease and squamouscell carcinoma showed a higher helper/suppressor T cell ratio than that in basal cell carcinoma. This maybe accounted for by a selective increased recruitment of helper T cells to the tumor infiltrates in Bowen'sdisease and squamous cell carcinoma.
• 中文關鍵字： skin-associated lymphoid tissue; arsenical skin cancer.
• 英文關鍵字： --