- 作者: 林東明
- 作者服務機構: Department of Public Health; College of Medicine; National Taiwan University
- 中文摘要: In a period of one and a half year retrospecctive study on nasopharyngealcarcinoma (NPC) in Taiwan, sera collected from NPC patients, age and sex matchedneighborhood (N) controls, NPC families, and neighborhood control (NC) familieswere titrated for antibodies to herpes-type virus (HTV) in a Burkitts lymphomacell line (P3HR-1) by the indirect immuno-fluorescence antibody technique. Dissocia-tions in the frequency distributions of antibody titers in NPC and the control groupswere found to be maximum when the limiting value was set at 1:640. Antibodytiters were higher in the NPC patients than in any of the 3 control groups bygeometric means, and significantly different by ridit analysis and chi-square test.Of 321 NPC patients 55% had anti-HTV antibody titers equal to or higher than1:640 while such values occurred in only 6% for the 3 control groups. There wasno sex difference in the percentages of "sero-positive" cases in ali the groups. Thedistributions of anti-HTV antibody titers between the cases of NPC and each of the3 control groups were significantly different. The relative risks indicated that persons with antibody titer equal to or higherthan 1:640 had more than 40 times the NPC risk of those with antibody titer ofless than 1:40. There were no significant differences in the geometric means anddistributions of anti-HTV antibody titers of the family members in the NPC patientsand the N controls by same titer of probands. The geometric means of anti-HTVantibody titers of the family members by different titers of probands, however,were higher for the both groups as the titer of the probands were higher, and thedistributions were significantly different for the both groups. There were nohousehold aggregations of high titers of anti-HTV antibody in both the familymembers of the NPC patients and the N controls. The significance and implcationsof these findings are discussed.
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