- 作者: Jasmine P Devadhasan; Sanghyo Kim; Jeongho An
- 作者服務機構: College of Bionanotechnology, Kyungwon University, Republic of Korea
- 中文摘要: --
- 英文摘要:
Microfluidics has become an important tool in diagnosing many diseases, including
neurological and genetic disorders. Alzheimer’s disease (AD) is a neurodegenerative disease
that irreversibly and progressively destroys memory, language ability, and thinking skills.
Commonly, detection of AD is expensive and complex. Fluorescence in situ hybridization
(FISH)-based microfluidic chip platform is capable of diagnosing AD at an early stage and
they are effective tools for the diagnosis with low cost, high speed, and high sensitivity. In
this review, we tried to provide basic information on the diagnosis of AD via FISH–based
microfluidics. Different sample preparations using a microfluidic chip for diagnosis of AD
are highlighted. Moreover, rapid innovations in nanotechnology for diagnosis are explained.
This review will provide information on dynamic quantification methods for the diagnosis
and treatment of AD. The knowledge provided in this review will help develop new
integration diagnostic techniques based on FISH and microfluidics. - 中文關鍵字: --
- 英文關鍵字: Fluorescence in situ hybridization (FISH), Microfluidic chip, Alzheimer's disease (AD), Nanoparticles, Molecular probes