- 作者: Celia Maria Quinonez-Flores, Susana Aidee Gonzalez-Chavez and Cesar Pacheco-Tena
- 作者服務機構: 1. Facultad de Medicina y Ciencias Biomedicas, Universidad Autonoma de Chihuahua, Circuito No.1, Nuevo Campus Universitario, Chihuahua C.P. 31240, Mexico 2. Facultad de Ciencias de la Cultura Fisica, Universidad Autonoma de Chihuahua, Circuito No.1, Nuevo Campus Universitario, Chihuahua C.P. 31240, Mexico
- 中文摘要: --
- 英文摘要:
Alterations in tissue oxygen pressure contribute to a number of diseases, including rheumatoid arthritis (RA). Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it is involved in angiogenesis, inflammation, apoptosis, cartilage degradation, energy metabolism, and oxidative damage. Therefore, alterations in hypoxia-related signaling pathways are considered potential mechanisms of disease pathogenesis. The objective of this review is to highlight and update our current knowledge of the role of hypoxia in the pathogenesis of RA. We describe the experimental evidence that RA synovial tissue exists in a hypoxic state, as well as the origin and involvement of synovial hypoxia in different aspects of the pathogenic process. - 中文關鍵字: --
- 英文關鍵字: Hypoxia-inducible factor (HIF), Autoimmune disease, Inflammation