• 作者： 劉克明; 張均昌
• 作者服務機構： 高雄醫學院解剖學科; 生物化學科
• 中文摘要： 有關靈長類動物之神經膠細胞內脂褐質顆粒之組織學上的研究極少。因此，本研究利用電子顯微鏡探討臺灣獼猴視神經之神經膠細胞脂褐質顆粒之微細構造。於星狀神經膠細胞之細胞質內，有許多不同形態的脂褐質顆粒，其特點為含有大形脂肪小滴，小形的高電子密度的色素顆粒以及一些板狀構造物。少樹突神經膠細胞之脂褐質顆粒，主要由密度高的粗大色素顆粒，多層絲狀構造物以及小量的小形脂肪小滴所構成。在微神經膠細胞內之脂褐質顆粒，具有許多不同大小之脂肪小滴，高電子密度的小形色素顆粒以及顯著的板樣膜狀結構物等特徵。過去一般一直認為脂褐質顆粒是一種衰竭細胞所產生之物質，亦即是低功能細胞的一種產物。然而，我們的觀察認為視神經神經膠細胞內之脂褐質顆粒是神經膠細胞經活躍進行吞噬作用後之特殊產物。
• 英文摘要： The ultrastructure of lipofuscin granules in neuroglial cells of the optic nerve of the Formosan Rock-Monkey was investigated by electron microscopy. In the cytoplasm of astroglial cells, numerous irregularlipofuscin granules were characterized by the presence of large lipid droplets, small electron-dense pigmentgranules, and some lamellar structures. The lipofuscin granules of the oligodendroglial cells were composedlargely of dense, coarse pigment granules, multilinear structures, and a few small lipid droplets. The lipi-fuscin granules in microglial cells were characterized by numerous lipid droplets in various sizes, smallelectron-dense pigment granules, and prominent lamellar structures. It was reported that the lipofuscingranules are wear-and-tear materials and products from the cells in lower functional activity. However, ourobservations suggest that the presence of lipofuscin granules in the neuroglial cells of the optic nerve islikely a characteristic product of active phagocytosis.
• 中文關鍵字： lipofuscin; neuroglia; optic nerve; Macaca cyclopis
• 英文關鍵字： --