- 作者: Yu-Jia Wang, Henry Sung-Ching Wong, Chung-Che Wu, Yung-Hsiao Chiang, Wen-Ta Chiu, Kai-Yun Chen and Wei-Chiao Chang
- 作者服務機構: 1. Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan 2. Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan 3.Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan 4. Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan 5. Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan 6. Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 7. Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan 8. Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan 9. Pain Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
- 中文摘要:
- 英文摘要:
Background
Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI.
Methods
Based on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases.
Results
The minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury.
Conclusions
IGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI. - 中文關鍵字:
- 英文關鍵字: Mild traumatic brain injury, Genetic variants, Insulin-like growth factor 1, Anxiety, Depression, Dizziness, Sleep disorders