- 作者: Shoichi Kusumoto*, Koichi Fukase, Masato Oikawa and Yasuo Suda
- 作者服務機構: Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan
- 中文摘要: Typical bacterial glycoconjugates are known to stimulate immunological systems of higher animals and thereby play important roles in the primary defense of animals against bacterial infection.Lipopolysaccharide (LPS) of gram-negative bacteria is a representative of such glycoconjugates.LPS was first discovered as a potent bacterial toxin and named endotoxin but was soon found to exhibit immunostimulating activity.By the use of our synthetic pure preparations, the lipophilic partial structure of LPS, designated lipid A, proved to be the active entity responsible for both endotoxic and immunostimulating activities of LPS.This paper deals with our recent chemical synthesis and functional study of lipid A and related compounds.Synthesis is described of its various structural analogues, radio-labeled compound and Re-type LPS that contains two additional sugar moieties linked to lipid A.
- 英文摘要: --
- 中文關鍵字: Synthesis; Glycoconjugates; Lipid A; Lipopolysaccharide; Biological activity; Cytokines; Immunostimulation; Innate immunity.
- 英文關鍵字: Synthesis; Glycoconjugates; Lipid A; Lipopolysaccharide; Biological activity; Cytokines; Immunostimulation; Innate immunity.