- 作者: 杜采潓 ; 王義烽 ; 吳明忠
- 作者服務機構: 高雄醫學院化學系
- 中文摘要: Several .alpha.-ketoalcohols of synthetic value were resolved using lipase as a catalyst. Lipoprotein lipase(LPL) provided the best rate of hydrolysis and kinetic differentiation. One of these optically pure .alpha.- ketoalcohol was converted to (S)- ibuprofen in good optical purity. The stereospecific inversion of (R)-alcohol to (S)- alcohol is described.
- 英文摘要: --
- 中文關鍵字: Enzymatic Resolution; Ketoalcohol; Ibuprofen; Lipase; Stereochemistry
- 英文關鍵字: 酵素解析;酮醇;.alpha.-甲基-4-異丁基-苯乙酸;脂肪酵素;立體化學