- 作者: Shun-Fen Tzeng
- 作者服務機構: Department of Biology, National Cheng-Kung University, Tainan, and Department of Research and Education, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
- 中文摘要: --
- 英文摘要: born rat spinal cords in combination with neurotrophicfactors may provide a tool for cell therapy in SCI pa-tients.Permanent functional deficit in patients with spinal cordinjury (SCI) is in part due to severe neural cell death.Therefore, cell replacement using stem cells and neuralprogenitors that give rise to neurons and glia is thoughtto be a potent strategy to promote tissue repair after SCI.Many studies have shown that stem cells and neural pro-genitors can be isolated from embryonic, postnatal andadult spinal cords. Recently, we isolated neural progeni-tors from newborn rat spinal cords. In general, the neuralprogenitors grew as spheres in culture, and showedimmunoreactivity to a neural progenitor cellular marker,nestin. They were found to proliferate and differentiateinto glial fibrillary acidic protein-positive astroglia andmultiple neuronal populations, including GABAergic andcholinergic neurons. Neurotrophin 3 and neurotrophin 4enhanced the differentiation of neural progenitors intoneurons. Furthermore, the neural progenitors that weretransplanted into contusive spinal cords were found tosurvive and have migrated in the spinal cord rostrallyand caudally over 8 mm to the lesion center 7 days afterinjury. Thus, the neural progenitors isolated from new-
- 中文關鍵字: --
- 英文關鍵字: Neurogenesis, Neural progenitor, Neurosphere, Cell transplantation, Cell migration