- 作者: Shun-miao Fang; Qing-hua Zhang; Zhi-xin Jiang
- 作者服務機構: Department of Cardiology, Southern Medical University (S.M.F.), Guangzhou, China;
- 中文摘要: --
- 英文摘要:
Background :
It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis
leads to acute coronary events and stroke. However, study of the mechanism and
treatment of human plaque rupture is hampered by lack of a suitable animal model.
Our aim was to develop a novel animal model of atherosclerotic plaque rupture to
facilitate the study of human plaque disruption and thrombosis.
Methods
28 healthy male New Zealand white rabbits were randomly divided into two groups:
rabbits in group A (n=12) were only fed a high-fat diet for eight weeks; rabbits in
group B (n=16) underwent cold-induced endothelial injury with liquid nitrogen, then
were given a high-fat diet for eight weeks. After completion of the preparatory
regimen, triggering of plaque rupture was attempted by local injection of liquid
nitrogen in both groups.
Results :
All rabbits in group B had disrupted plaques or rupture-driven occlusive thrombus
formation, but none in group A showed any effects. More importantly, the
cold-induced plaques in our model were reminiscent of human atherosclerotic plaques
in terms of architecture, cellular composition, growth characteristics, and patterns of
lipid accumulation.
Conclusions :
We successfully developed a novel rabbit model of atherosclerotic plaque rupture and
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thrombosis, which is simple, fast, inexpensive, and reproducible, and has a low
mortality and a high yield of triggering. This model will allow us to better understand
the mechanism of human plaque rupture and also to develop plaque-stabilizing
therapies. - 中文關鍵字: --
- 英文關鍵字: --