- 作者: Chung-Eun Ha; Ji-Sook Ha; Andre G Theriault; Nadhipuram V Bhagavan
- 作者服務機構: Department of Native Hawaiian Health, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
- 中文摘要: --
- 英文摘要:
Statins reduce cholesterol biosynthesis by inhibiting HMG-CoA reductase and thereby
lower total cholesterol and LDL cholesterol levels in serum, which in turn lower the incidence of
cardiovascular disease (CVD). Statins are also known to modulate various cellular functions
such as gene expression, cell proliferation, and programmed cell death through inhibition of
downstream intermediates in cholesterol synthesis. In this study, we have investigated the
possible effects of statins on the secretion of serum albumin from cultured HepG2 cells since
high levels of serum albumin are associated with reduced risks for CVD and statins are effective
in lowering the risk of CVD through other effects in addition to their effects on serum total
cholesterol and LDL cholesterol levels, known as pleiotropic effects. Our results showed that
simvastatin increased HSA secretion up to 32.3% compared to the control group. Among 3
statin analogs we tested, simvastatin exhibited the highest stimulatory effects on HSA secretion
compared to the control group. Our study also showed that the increased HSA secretions from
HepG2 cells by simvastatin treatments were due to the increased rate of HSA synthesis, not due
to the reduced posttranslational degradation rate of HSA. Our finding suggests another added
benefit of statins’ treatments in preventing CVD through stimulation of HSA biosynthesis. - 中文關鍵字: --
- 英文關鍵字: --