- 作者: Shern-Fwu Lee; Jen-Kun Lin
- 作者服務機構: Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: Benzene is strongly suspected of being an animal and human carcinogen, but the mechanisms by which it induces tumors of lymphoid and hematopoietic organs are unknown. Production of active oxygen species from benzene metabolites [hydroquinone (HQ), catechol and 1,2,4-benzenetriol (1,2,4-BT) and related polyphenols (resorcinol, pyrogallol and phloroglucinol) are investi- gated. Pyrogallol and 1,2,4-BT can produce H2O2, O2- and ˙OH simultaneous- 1y, and have powerful mutagenic potential. Resorcinol and phloroglucinol can- not produce all of the active oxygen species, and show no mutagenic effects. Catechol can produce H2O2, but cannot produce O2- and ˙OH, and has no mutagenic activity. These data strongly support the hypothesis that benzene metabolites can cause mutagenicity via the generation of oxygen radicals. Although HQ produces H2O2 only, and less than produced by pyrogallol and 1,2,4-BT, the mutagenicity of HQ is higher. The results indicate that HQ may act via another mechanism to cause mutagenicity. In the presence of trace metal ions, the reactivity of polyphenols is increased. The biological signifi- cance of these phenomena are investigated and discussed.
- 中文關鍵字: --
- 英文關鍵字: Polyphenols; Benzene metabolites; Hydroquinone; Catechol; 1,2,4-Benzenetriol; Pyrogallol; Active oxygen species; Hydrogen peroxide; Superoxide radical; Hydroxyl free radical