- 作者: Elisardo C Vasquez, Veronica A Peotta, Agata L Gava, Thiago MC Pereira and Silvana S Meyrelles
- 作者服務機構: Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil.
- 中文摘要: --
- 英文摘要:
Cardiovascular death is frequently associated with atherosclerosis, a chronic multifactorial disease
and a leading cause of death worldwide. Genetically engineered mouse models have proven useful for the
study of the mechanisms underlying cardiovascular diseases. The apolipoprotein E-deficient mouse has
been the most widely used animal model of atherosclerosis because it rapidly develops severe
hypercholesterolemia and spontaneous atherosclerotic lesions similar to those observed in humans. In
this review, we provide an overview of the cardiac and vascular phenotypes and discuss the interplay
among nitric oxide, reactive oxygen species, aging and diet in the impairment of cardiovascular function in
this mouse model. - 中文關鍵字: --
- 英文關鍵字: Hypercholesterolemia, atherosclerosis, mouse, cardiac function, vascular senescence