- 作者: Chi V. Dang; Brian C. Lewis
- 作者服務機構: a Departments of Medicine, Oncology, Pathology, and Molecular Biology and Genetics, and; b Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Md., USA
- 中文摘要: --
- 英文摘要: The myc gene was initially discovered as a prototypical retrovirally transduced oncogene. Over the decades, abundant evidence has emerged to support a causal role for the activated cellular gene, c-myc, in animal and human tumors. The gene encodes an oncogenic helix-loop-helix leucine zipper transcription factor that acts as a heterodimer with its partner protein, Max, to activate genes regulating the cell cycle machinery as well as critical metabolic enzymes. The additional ability of c-Myc to repress transcription of differentiation-related genes suggest that c-Myc is a central and key molecular integrator of cell proliferation, differentiation and metabolism.
- 中文關鍵字: --
- 英文關鍵字: c-Myc; Oncogene; Transcription; Cancer; Metabolism; Apoptosis