- 作者： 林孫權
- 作者服務機構： 台灣省立屏東農業專科學校
- 中文摘要：
台灣省畜產試驗所恒春分所自民國六十二年七月至六十四年七月為所發生感光過敏症牛中，十六頭進
行臨床、血液與尿液之生化及組織病理檢查。病牛以二歲以下居多，病初搖頭擺耳，頗為不安，鼻鏡、耳
翼或其他色素較少之皮膚部位發生皮膚炎。除外，全身黏膜黃染，食慾不振或廢絕，經三～四週
即可痊癒。部分病重牛可在一～二週死亡。本病有溶血性貧血。病初血中膽紅素及膽固醇均顯著
增加，SGO-T及SAP等血中?之活動性輕度增加；隨病程之經過呈現逐漸下降，至二～三週即
回復原正常值。尿液化學檢查：病初期除部分病牛（5∕11）現尿蛋陽性外，所有受檢病牛（十一
頭）病初期均呈尿膽紅素陽性而尿膽素原陰性，至病中期以後，尿蛋白及尿膽紅素均轉為陰性，
而尿膽素原則呈現±～十程度之陽性。從病牛血液及尿縮生化檢查所得，顯示本病之黃疸，膽
管阻塞性重要於肝細胞性。連續肝生檢及解剖檢查顯示病牛肝臟有明顯膽管炎及微血管炎之組織
病變，肝細胞則僅呈輕微之脂肪變性而已。生化檢查及組織病變之研究結果，可斷定本病在某病
因之作用下，造成以膽管炎為主，致膽汁排泄困難而發生黃疸。本病乃是一種肝原性感光過敏症。 - 英文摘要： Sixteen cattle natarally affected withphotosensitization have been investigated ontheir disease nature during July 1973 toJuly, 1975 in Hungchung Stationm, TaiwanProvincial Livestock Research Institute. Thedisease attacked young cattle less than twoyears of age, and was happened in hot andrainy season mostly. The characteristic signs of the diseasewere restlessness with some evidence of ic-terus, anemia and dermatitis. The skin lesionwas restricted in less or non-pigmented areas-muzzle, ear lap, and udder etc. The dura-tion of the disease was about 3 to 4 weeks.Most of the animals were recovered. Deathoccurred within weeks in very severely affec-ted animals. Liver function tests revealed marked inc-rease of serum bilirubin and serum choleste-rol, but mild increase of serum glutamic lox-alacetic transaminase (SGO-T) and serumalkaline phosphatase (SAP) activities at thefirst week of the course. These serum con-tents gradually reduced to normal level afterone or two weeks. In urine examination, all the samples(llcases) indicated that bilirubin was verydetectable without the presence of urobilino-gen within the first week. This phenomenonpersisted about 10 days. After that bilirubinwas disappeared, and urobilinogen was thendetectable. Hemoglobinuria was also noticedduring the course in some cases· Cholangitis and Cholangiolitis were mainlesions found in histopathological examination,Parenchymatous degeneration was mild in de-gree in most cases. The results of biochemical and histopatho-logical studies proved that jaundice was occ-urred mainly from the temporary obstrutc-tion of bile ducts. It was a kind of hepato-genous photosensitization. The agents thatcaused this disorder had not been determinedin this study.
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