- 作者: 林漢欽; 金明儒; 蘇慕寰; 陳甘霖; 王金子
- 作者服務機構: School of Pharmacy, National Defense Medical Center, Taipei, Taiwan 107
- 中文摘要: The alcoholic extract of Gymnosporia trilocularis Hay. (Celastraceae) was found to exhibit antitumer activities against P388 lymphocytic leukemia and KB cell culture systems. From this extract β-amyrin (1), β-sitosterol (2) and its monoglucoside (6), stigmasterol (3) and its monoglucoside (7), campesterol (4) and its monoglucoside (8), maniladiol (5), dulcitol (9) and six yet unidentified principles (10-15) were isolated. The stereochemistry of C-16-OH of maniladiol (5) was confirmed spectroscopicaclly by 1H nmr to be equatorial. Of all the isolated compounds, the mixture of three steroid monoglucosides (6:7:8=28:1:1:1) exhibited cytotoxicity (ED50=2.6×10..mcg/ml) and 5 showed only marginal effect (ED50=2.1×10..mcg/ml) in KB test system.
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --