• 作者： 鄭啟清; Gabriel Fernandes
• 作者服務機構： Department of Medical Research, Taichung Veterans General Hospital ; Division of Clinical Immunology, Department of Medicine, University of Texas health Science Center at San Antonio
• 中文摘要： 　　本實驗以不同非飽和油脂飼料，餵養正常NZW／N小老鼠及自體免疫病NZB／NZW小老鼠，探討對免疫反應及尿蛋白的影響。小老鼠分五組：低脂（5％）玉米油，限食組，高脂（20％）同熱量的玉米油或魚油，另以標準飼料組為對照組；飼養一年以上。結果顯示，正常小老鼠以魚油飼養，其抗綿羊血之抗體反應比年青或限食的差，它對介白質二的利用也不佳，玉米油組也是同樣的差。自體免疫的小老鼠餵以魚油後，其抗體反應不好，且其利用介白質二的能力，比其他組顯著的壞。另一方面，介白質一的生成，在魚油及玉米油組均見降低。然而，魚油組的小老鼠和限食組一樣，它的尿蛋白很低而且存活率較高，暗示抑制免疫的作用可能和魚油的功效有部分關係。
• 英文摘要： In this study, we examined the immune response and proteinuria caused by dietary polyunsaturatedfatty acids in normal NZW/N and autoimmune NZB/NZW mice. Mice were maintained more than one yearon five dietary groups: normal (5% corn oil), calorie-restricted, high fat (20% corn oil), high fat (20% fishoil), and Purina laboratory rodent chow. Normal mice fed with the fish oil diet had a more reduced anti-sheep red blood cells (SRBC) plaque-forming cell (PFC) response and less interleukin-2 (IL-2) enhancementof PFC than did the group with the restricted diet and the young control group. The corn oil (5 and 20%)diet animals also showed reduced PFC response and IL-2 utilization. NZB/NZW mice fed with the fish oildiet showed similar reduced PFC response but had a significantly lower response to IL-2 than did those onthe corn oil diets and the restricted diet. The IL-2 production by macrophages from NZW/N mice wasreduced in both the fish oil and corn oil diet groups. However, mice fed with the fish oil diet had less pro-teinuria and good survival rates, similar to the group with the restricted diet. These results suggest that thebeneficial effect of the fish oil diet in these animals may be attributed in part to the immunosuppressionmechanism.
• 中文關鍵字： fish oil; antibody response; IL-1; proteinuria
• 英文關鍵字： --