• 作者： 張哲壽; 鍾國雄; 高壽延
• 作者服務機構： 台北榮民總醫院牙科部口腔顎面外科; 國立陽明醫學院牙醫學系
• 中文摘要： 以10隻台灣獼猴作為研究對象，在其兩側股骨上端磨出長、寬、深各約12毫米之骨缺損並植入顆粒氫氧磷灰石。在猴子分別飼養至術後之1、2、3、6、8個月時將其犧牲並取下其種植區標本，隨機選擇其一側之標本進行組織學觀察，另一側標本則用來測量其垂直抗壓強度。在組織觀察方面，術後1個月時氫氧磷灰石顆粒間僅存在疏鬆之纖維組織，2個月後可見到網狀的新生骨出現在種植區基底部之氫氧磷灰石周圍，至3個月後新生骨延伸至種植區之中央部份，種植區之骨化現象持續至術後6至8個月始達完全。在標本之垂直抗壓強度研究方面則顯示出與組織觀察結果相類似之變化，所測得之標本彈性係數值在第1個月時相當的低，隨著纖維組織的癒合成熟、氫氧磷灰石顆粒的逐漸緊密及骨化現象的產生，彈性係數值至3個月後已較股骨相同部位之皮質骨高，至8個月後可達皮質骨之2倍強。本研究之結果可提供關於顆粒氫氧磷灰石在宿主骨缺損種植區內組織癒合過程與垂直承受力間關係之重要資料。
• 英文摘要： Bony defects measuring 12x12x12 millimeters in size were created bilaterally over the proximal endof the femurs of 10 Macaca cyclopis monkeys and implanted with particulate hydroxylapatite. The animalswere sacrificed according to a predetermined sequence of post-operative 1, 2, 3, 6, and 8 months. Thespecimens taken from the implant sites in the two femurs of each animal were chosen randomly either forhistological observation or for compressive strength tests under vertical loads. Histological pictures showedonly loose fibrous tissue over the interparticular space of the implant site at the first month after surgery.Woven bone could be observed over the basal part of the implant site at the second month. New boneformed over the central part of the implant site at the third month after surgery. Continuing maturationof the bone tissue could be observed over the interparticular space of the implant site until the late stagesat the 6th and 8th month after surgery. The results of compressive strength tests were compatible with thehistological observations. The value of the elastic modulus was low initially at the first month, but in-creased gradually with time due to organization of fibrous tissue, condensation of HA particles, and ossifica-tion as well as maturation of bone tissue. The value of elastic modulus at the third month was equal tothat of cortical bone tissue and even two-fold higher than that of the cortocal bone at the eighth monthafter surgery. These results provide valuable information about the compressive strength of the HA implantin host tissue.
• 中文關鍵字： Macaca cyclopis; hydroxylapatite; biomechanics.
• 英文關鍵字： --