- 作者: --
- 作者服務機構: University of Cologne, Institute of Organic Chemistry, Greinstr. 4, D-50939 Koln, Germany
- 中文摘要: The synthesis of a series of 5-cyclopropyl substituted 1,2,4-trioxanes 3a-3f by a sequence of singlet oxygen ene reaction with the 1-cyclopropylated allylic alcohol 1 and subsequent peroxyacetalization reaction with aldehydes and ketones, respectively, is described. An important side reaction is the formation of cross-peroxyacetalization products 4 and 5 from the Lewis-acid catalyzed cleavage of the initially formed b-hydroperoxy alcohol 2. The in vitro antimalarial activities of several derivatives 3 against Plasmodium falciparum are remarkably high.
- 英文摘要: --
- 中文關鍵字: Ene reaction; Singlet oxygen; Trioxanes; Peroxyacetalization; Catalysis.
- 英文關鍵字: --