- 作者: Ajay KUMAR Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram, Ravi Mehrotra
- 作者服務機構: Centre for Biotechnology, University of Allahabad, Allahabad, India
- 中文摘要: --
- 英文摘要:
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that
are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of
matrix is a key event in progression, invasion and metastasis of potentially malignant
and malignant lesions of the head and neck. It might have an important polymorphic
association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G),
MMP-2 (–1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-
418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally
occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the
breakdown of ECM. Currently, many MMP inhibitors (MMPIs) are under
development for treating different malignancies. Useful markers associated with
molecular aggressiveness might have a role in prognostication of malignancies and to
better recognize patient groups that need more antagonistic treatment options.
Furthermore, the introduction of novel prognostic markers may also promote
exclusively new treatment possibilities, and there is an obvious need to identify
markers that could be used as selection criteria for novel therapies. The objective of
this review is to discuss the molecular functions and polymorphic association of
MMPs and TIMPs and the possible therapeutic aspects of these proteinases in
potentially malignant and malignant head and neck lesions. So far, no promising drug
target therapy has been developed for MMPs in the lesions of this region. In
conclusion, further research is required for the development of their potential
diagnostic and therapeutic possibilities. - 中文關鍵字: --
- 英文關鍵字: --