- 作者: 簡偉明 ; 陳清玉 ; 蘇聖芳
- 作者服務機構: 成功大學醫學系藥理科
- 中文摘要: A potent thromboxane antagonist, 1-[2-(2-carboxyethyl)benzyl]]-2-benzenesulfonamidobicyclo-[2.2.1] heptane was synthesized from norcamphor in 8 steps. It was shown to be a very potent thromboxane antagonist by inhibition of platelet aggregation induced by U46,619 at nanomolar concentration. The key intermediate 3-[2-bromomethylphenyl] propyl tetrahydropyran ether may be useful for the synthesis of other interphenylene containing prostaglandin analogs.
- 英文摘要: --
- 中文關鍵字: Thromboxane Antagonists; Platelet Aggregation; Antagonist; Benzenesulfonamidobicyclo Heptane
- 英文關鍵字: 前列線素阻抗劑;血小板凝集;阻抗劑;苯磺胺二環七烷