- 作者: Eaton, Philip E. ; 熊豫生 ; 李志宏
- 作者服務機構: Dept. of Chemistry, Univ. of Chicago, Chicago, Illinois, U.S.A.
- 中文摘要: Metalation of 2,4-dicyanocubanecarboxamide with lithium tetramethylpiperidide (LiTMP) followed by quenching with CO/sub 2/ is non-regioselective and results in carboxylation at the 3(.arrr.5) and 6(.arrr.6) positions. However, when the reaction was repeated with LiTMP pre-treated with more than 0.5 equivalent of MgBr/sub 2/, only 6 was produced. This was shown to occur by direct, regiospecific ortho-magnesiation by the bases BrMgTMP and MgTMP/sub 2/. This initial observation of ortho- magnesiation has opened the way to wide application of this new methodology, a valuable and useful complement to ortholithiation.
- 英文摘要: --
- 中文關鍵字: Ortho-Magnesiation; Cubane; Metalation
- 英文關鍵字: 金屬化