- 作者: Tianci Luo; John L. Foster; J. Victor Garcia
- 作者服務機構: Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tenn., USA
- 中文摘要: --
- 英文摘要: The human immunodeficiency virus (HIV), the causative agent of the acquired immune deficiency syndrome (AIDS), in addition to encoding for the gag, pol and em structural genes common to all retroviruses also encodes six accessory genes: tat, rev, nef, vpr, vpu and vif. These accessory genes are responsible for the regulation of HIV replication. Recent advances in our understanding of the function(s) of these genes have illustrated the complex interplay between HIV, the infected cell and the host. In addition, identification of cellular proteins interacting with accessory gene products have provided new tools to study cellular processes. The topic of this review, nef, has been shown in vitro to induce the cell surface downregula-tion of CD4, the receptor for HIV, to enhance the infectivity of HIV particles and to associate with at least one cellular serine/threonine kinase. In vivo, Nef is essential for the efficient virus replication responsible for disease progression. In this review, several prominent aspects of Nef function are discussed including its effect on CD4 trafficking, on signaling pathways and on virus infectivity enhancement.
- 中文關鍵字: --
- 英文關鍵字: HIV/SIV; Nef; CD4; MHC class I ; Serine kinase ; PAK kinase ; Animal models