- 作者: 張錦得; 張文旺
- 作者服務機構: Union Industrial Research Laboratories, Industril Technology Research Institute, Hsinchu, Taiwan 300
- 中文摘要: An improved method of the preparation of 4-amino-6-chloropyrimidine, the important intermediate of a sulfa drug sulfamonomethoxine, by chlorination of 4-amino-6-hydroxypyrimidine with phosphorus oxychloride in DMF is described. The reaction pathway is proved by the iso;ation of the reaction intermediates, 4-dimethylformamidino-6-chloropyrimidine and 4-formylamino-6-chloropyrimidine. The hydrolysis of these intermediates is extensively studied under different conditions.
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --