- 作者: Shih-Hua Fang Ming-yang Lai Lih-Hwa Hwang pei-Ming Yang Pei-Jer chen bor-Luen chiang ding-Shinn chen
- 作者服務機構: Graduate Institute of Microbiology, Graduate Institute of Clinical Medicine, department of Internal Medicine, Hepatitis research Center, collenge of Medicine, National Taiwan University, Taipei, Department of Medicine, china Medical College, taichung, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Some patients with chronic hepatitis C respond to inter-feron (IFN)- treatment, and the efficiency can be im-proved by combining it with ribavirin. The mechanism ofthis improvement is unknown. To investigate the effectsof these two regimens on the immune responses in 51patients with chronic hepatitis C, we examined the hepa-titis C core antigen-specific proliferative response andcytokine production profiles, natural killer (NK) cell cyto-toxicity and cytotoxic T cell function during treatment.The results are as follows: (1) both viral clearance andbiochemical normalization occurred more frequently inpatients receiving combination therapy; (2) the functionof NK cells increased after treatment in the responders ofboth groups (p<0.05); (3) the level of IFN- produced byhepatitis C core antigen-stimulated peripheral bloodmononuclear cells was higher in patients receiving com-bination therapy, especially in responders; (4) the coreantigen-specific proliferative response decreased aftertreatment, and (5) in addition, the core-specific cytotoxicT cell activities of five responder patients also increasedsignificantly after therapy. In conclusion, enhancementof immune responses, especially those related to type-1T helper cell activity, may contribute to better efficacy incombining ribavirin with IFN- for treatment of chronichepatitis C.
- 中文關鍵字: --
- 英文關鍵字: Ribavirin. Hepatitis C. Combination therapy. Interferon-r