- 作者: Chun-Chou Tsai; Bor-Show Tzang; Szu-Yi Chiang; Gwo-Jong Hsu; Tsai-Ching Hsu
- 作者服務機構: Institute of Immunology, Chung Shan Medical University, Taichung, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要:
Background: Human parvovirus B19 infection has been postulated to the
anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of
anti-B19-VP1u antibody in autoimmune diseases is still obscure.
Methods: To elucidate the effect of anti-B19-VP1u antibodies in systemic lupus
erythematosus (SLE), passive transfer of rabbit anti-B19-VP1u IgG was injected
intravenously into NZB/WF1 mice.
Results: Significant reduction of platelet count and prolonged thrombocytopenia time
were detected in anti-B19-VP1u IgG group as compared to other groups, whereas
significant increases of anti-B19-VP1u, anti-phospholipid (APhL), and anti-double strand
DNA (dsDNA) antibody binding activity were detected in anti-B19-VP1u group.
Additionally, significant increases of matrix metalloproteinase-9 (MMP9) activity and
protein expression were detected in B19-VP1u IgG group. Notably, phosphatidylinositol
3-phosphate kinase (PI3K) and phosphorylated extracellular signal-regulated kinase
(ERK) proteins were involved in the induction of MMP9.
Conclusions: These experimental results firstly demonstrated the aggravated effects of
anti-B19-VP1u antibody in disease activity of SLE. - 中文關鍵字: --
- 英文關鍵字: --