- 作者: Xiaoli Dai; Claude D. Brunson; Robin W. Rockhold; Horace H. Loh; Ing K. Ho; Tangeng Ma
- 作者服務機構: Department of Anesthesiology,University of Mississippi Medical Center,MS, USA; Department of Pharmacology and Toxicology,University of Mississippi Medical Center, MS, USA; Department of Pharmacology,University of Minnesota Medical School,Minneapolis, MN, USA
- 中文摘要: --
- 英文摘要: Gender difference in the antinociceptive effectof tramadol and gabapentin (alone or in combination) wereinvestigated in mice. For investigation of acute antinociceptiveeffect, tramadol and gabapentin were administeredto mice by intraperitoneal injection and per os, respectively,and antinociceptive activity was measured by thetail-flick test 30 min after drug administration. For investigationof the development of antinociceptive tolerance toanalgesics, mice were injected with tramadol (60 mg/kg),alone or in combination with gabapentin (75 mg/kg), twicedaily for seven consecutive days and the tail-flicks weretested on experimental days 1, 3, 5 and 7. Results showedthere was a lower ED50 value of tramadol antinociceptionin males than in females, indicating that females were lesssensitive to the drug. Gabapentin produces a limited antinociceptionin both males and females. The combinationof gabapentin and tramadol produced synergistic effectwithout gender difference. Repeated administration oftramadol produced antinociceptive tolerance in both genders.Gabapentin produced synergistic effect in tramadoltolerantmice and repeated administration of gabapentin didnot alter the synergistic effect in tramadol-tolerant mice.Because females show a higher overall prevalence of painand less sensitivity to opioids, our finding may suggest aclinical significance of combined use of the two drugs.
- 中文關鍵字: --
- 英文關鍵字: Tramadol; Gabapentin; Pain; Antinociception; Tolerance; Mice; Tail-flick; Opioid receptor; Gender