- 作者: Adel. M. Kamal El-Dean* and Maisa E. Abdel-Moneam
- 作者服務機構: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
- 中文摘要: 5-Ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6(1H)-thione (3), which was prepared from the reaction of ethyl b-aminocrotonate 1 with benzoyl isothiocyanate (2) in refluxing acetone, was reacted with halo compounds to give S-alkyl derivatives 4a-h. Treatment of compounds 4a-c with sod. Ethoxide cyclized into thienopyrimidine 10a-c. Hydrazinolysis of compound 3 gave hydroxypyrazolopyrimidine derivative 6. Also the latter compound was obtained upon heating compound 4a with hydrazine hydrate under neat conditions, but when compound 4a refluxed with hydrazine hydrate in ethanol the corresponding carbohydrazide 5 was produced.
- 英文摘要: --
- 中文關鍵字: Synthesis; Pyrimidines; Thienopyrimidines and pyrazolopyrimidines
- 英文關鍵字: Synthesis; Pyrimidines; Thienopyrimidines and pyrazolopyrimidines