- 作者: Chi-Lun Chang ; Mu-En Lin; Hsien-Yeh Hsu; Chao-Ling Yao; Shiaw-Min Hwang; Chien-Yuan Pan; Chi-Yen Hsu; Hsinyu Lee
- 中文摘要: --
- 英文摘要: Lysophophatidic acid (LPA), a low-molecular-weight lysophospholipid enriched in platelets and mildly oxidized low-density lipoproteins, is known to regulate inflammation and atherosclerosis by binding to its cognate receptors. In this study, we reported that LPA upregulated interleukin-1β (IL- 1β) expression in mouse J774A.1 macrophages. By using pharmacological inhibitors, it was suggested that Gi/Rho activation and subsequent reactive oxygen species (ROS) production were involved in IL-1β induction. In addition, IL-1 β induction by LPA was also observed in human primary macrophages. In summary, LPA is involved in the processes of inflammation by affecting macrophage behavior.
- 中文關鍵字: --
- 英文關鍵字: LPA.Macrophage . IL-1β · ROS . Inflammation