- 作者: Chu-Shek Lo; Terry Tamaroglio; Jing Zhang
- 作者服務機構: Department of Physiology, Uniformed; Services University of the Health Sciences, Bethesda, Md., USA
- 中文摘要: --
- 英文摘要: Induction of Fibronectin (FN) gene expression by platelet-derived growth fac- tor (PDGF) isoforms in rat thoracic aortic smooth muscle cells (SMC) was examined. PDGF-BB enhances FN levels in SMC cultures in a time- and con- centration-response fashion. PDGF-AA and PDGF-AB show no effect on FN levels. The effects of insulin and insulin-like growth factor-I (IGF-I) on PDGF- BB-induced FN levels were examined. No additivity of FN levels is observed between PDGF-BB and insulin and/or IGF-I. Experiments also show that PDGF-BB enhances FN mRNA levels, implying that acquisition of additional FN mRNA units accounts for the increase in FN levels. Induction of FN and FN mRNA levels by PDGF-BB could be one of the initial events in vascular SMC proliferation and extracellular matrix expansion, leading to atheroscle- rosis and hypertension.
- 中文關鍵字: --
- 英文關鍵字: Platelet-derived growth factors; Fibronectin; Vascular smooth muscle cells; Insulin; Insulin-like growth factor-I; Fibronectin mRNA