- 作者: Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo and Tang-Long Shen
- 作者服務機構: 1. Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan 2. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA 3. Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan 4. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan 5. Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan 6. Center for Biotechnology, National Taiwan University, Taipei, Taiwan
- 中文摘要:
- 英文摘要:
Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of cancer through its development and posttreatment evolve over time. Tumor-derived EVs are profoundly involved in this process and can, therefore, provide valuable real-time information to reflect dynamic changes occurring within the body. Because they bear unique molecular profiles or signatures, tumor-derived EVs have been highlighted as valuable diagnostic and predictive biomarkers as well as novel therapeutic targets. In addition, the use of an advanced EV-based drug delivery system for cancer therapeutics has recently been emphasized in both basic and clinical studies. In this review, we highlight comprehensive aspects of tumor-derived EVs in oncogenic processes and their potential clinical applications. - 中文關鍵字:
- 英文關鍵字: Extracellular vesicles, exosome, tumor-derived EVs, homeostasis, tumor microenvironment, EV isolation, biomarker, drug delivery