- 作者: Godwin A. Ponuwei
- 作者服務機構: Cell migration laboratory, Molecular and Cellular Medicine Unit, Department of Biomedical Sciences, School of Biological Sciences, Hopkins Building, University of Reading, Whiteknights, Berkshire, UK
- 中文摘要: --
- 英文摘要: In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous proteins involved in linking the plasma membrane to the cortical actin cytoskeleton. This review takes a succinct look at the biology of the ERM proteins including their structure and function. Current reports on their regulation that leads to activation and deactivation was examined before taking a look at the different interacting partners. Finally, emerging roles of each of the ERM family members in cancer was highlighted.
- 中文關鍵字: --
- 英文關鍵字: Ezrin, Radixin, Moesin, Plasma membrane, Phospholipids, Cancer