- 作者: 王恭
- 作者服務機構: Dept. of Chemistry, West Virginia Univ., Morgantown, West Virginia, U.S.A.
- 中文摘要: The thermal cycloaromatization reactions of (Z)-3- hexene-1,5-diynes(enediynes) and (Z)-1,2,4-heptatrien-6- ynes (enyne-allenes) provide easy entries to a variety of carbon biradicals. Several new synthetic routes to these highly unsaturated compounds were developed by using multifunctional reagents properly substituted with combinations of boron, silicon, and tin appendages. Condensation of .gamma.-(trialkylsilyl)allenylboranes with conjugated acetylenic and allenic aldehydes followed by the elimination step of the Peterson olefination reaction furnished enediynes and enyne-allenes with high geometric purity. Convenient procedures for the synthesis of enediynes and enyne-allenes were also developed by using alkenylboronic ester and the trimethyltin-substituted alkenylboranes for cross-coupling reactions. On heating, acyclic enyne-allene underwent a sequence of intramolecular transformations through biradical intermediates to form tetracyclic structure, providing a new example of a one- step 0.arrr.ABCD ring construction of the tetracyclic steroidal skeleton.
- 英文摘要: --
- 中文關鍵字: Enediyne; Enyne; Allene; Thermal Cycloaromatization Reaction; Synthesis
- 英文關鍵字: 烯二炔;烯炔;重烯;熱環芳香化反應;合成