- 作者: --
- 作者服務機構: Chemistry Department, Faculty of Science, Faiyoum University, Faiyoum, Egypt
- 中文摘要: Oxidative cyclization of the sugar hydrazones (3a-f) derived from {7H-1,2,4-triazolo[1,5-d]tetrazol-6-ylsulfanyl}acetic acid hydrazide (1) and aldopentoses 2a-c or aldohexoses 2d-f with bromine in acetic acid in the presence of anhydrous sodium acetate, followed by acetylation with acetic anhydride gave the corresponding 2-(per-O-acetyl-alditol-l-yl)-5-methylthio{7H-1,2,4-triazolo[1,5-d]tetrazol-6-yl}-1,3,4-oxadiazoles (5a-f). Condensative cyclization of the sugar hydrazones (3a-f) by heating with acetic anhydride gave the corresponding 3-acetyl-2-(per-O-acetyl-alditol-1-yl)-2,3-dihydro-5-methylthio{7-acetyl-1,2,4-triazolo[1,5-d]tetrazol-6-yl}-1,3,4-oxadiazoles (11a-f). De-O-acetylation of the acyclo C-nucleoside peracetates (5 and 11) with methanolic ammonia afforded the hydrazono lactones (7) and the acyclo C-nucleosides (12), respectively. The structures of new oxadiazole derivatives were confirmed by analytical and spectral data.
- 英文摘要: --
- 中文關鍵字: {7H-1,2,4-Triazolo[1,5-d]tetrazol-6-ylsulfanyl}acetic acid hydrazide; Sugar hydrazones; Cyclization; 1,3,4-Oxadiazole acyclo C-nucleosides.
- 英文關鍵字: --