- 作者: Kuan Wang, Yi-Fong Chen, Yu-Chen S. H. Yang, Haw-Ming Huang, Sheng-Yang Lee, Ya-Jung Shih, Zi-Lin Li, Jacqueline Whang-Peng, Hung-Yun Lin & Paul J. Davis
- 作者服務機構: 1.Cancer Center, Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Xinglong Road, Wenshan District, Taipei City, 116, Taipei, 11031, Taiwan 2.Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei, 11031, Taiwan 3.Department of Medicine, Albany Medical College, Albany, NY12144, USA 4.Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan 5.Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taipei, 11031, Taiwan 6.Joint Biobank, Office of Human Research, Taipei Medical University, Taipei, 11031, Taiwan 7.Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, 12144, USA 8.School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan 9.TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan 10.Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, 11031, Taiwan
- 中文摘要:
- 英文摘要:
Heteronemin (Haimian jing) is a sesterterpenoid-type natural marine product that is isolated from sponges and has
anticancer properties. It inhibits cancer cell proliferation via diferent mechanisms, such as reactive oxygen spe‑
cies (ROS) production, cell cycle arrest, apoptosis as well as proliferative gene changes in various types of cancers.
Recently, the novel structure and bioactivity evaluation of heteronemin has received extensive attention. Hormones
control physiological activities regularly, however, they may also afect several abnormalities such as cancer. L-Thyrox‑
ine (T4), steroid hormones, and epidermal growth factor (EGF) up-regulate the accumulation of checkpoint pro‑
grammed death-ligand 1 (PD-L1) and promote infammation in cancer cells. Heteronemin suppresses PD-L1 expres‑
sion and reduces the PD-L1-induced proliferative efect. In the current review, we evaluated research and evidence
regarding the antitumor efects of heteronemin and the antagonizing efects of non-peptide hormones and growth
factors on heteronemin-induced anti-cancer properties and utilized computational molecular modeling to explain
how these ligands interacted with the integrin αvβ3 receptors. On the other hand, thyroid hormone deaminated
analogue, tetraiodothyroacetic acid (tetrac), modulates signal pathways and inhibits cancer growth and metastasis.
The combination of heteronemin and tetrac derivatives has been demonstrated to compensate for anti-proliferation
in cancer cells under diferent circumstances. Overall, this review outlines the potential of heteronemin in managing
diferent types of cancers that may lead to its clinical development as an anticancer agent. - 中文關鍵字:
- 英文關鍵字: Heteronemin, Anticancer, Sponge, Marine sesterterpenoids, Integrin αvβ3