- 作者: 連金城、陳勝智、黃麗嬌、郭盛助
- 作者服務機構: Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, R.O.C.
- 中文摘要: In our study on the 1D and 2D NMR spectra of synthetic chalcones in DMSO-d6, we found that, contrary to our expectation, the signals of a-carbon correlated to the olefinic protons resonating at lower field whereas the signals of b-carbon correlated to the olefinic protons resonating at higher field in the spectra of chalcones. To further investigate such solvent effect, four a,b-unsaturated ketones were prepared and studied separately in CDCl3 and DMSO-d6. The result indicated that the a,b-unsaturated ketones that possess benzoyl moiety experienced solvent effect in DMSO-d6 to result in an anomalous chemical shift. The shift arose from the complexation of solute molecule with DMSO that fixed the steric conformation of solute molecule so that Hb was kept apart from its benzene ring whereas its Ha became more accessible by its benzene ring. Thus, these two olefinic protons would experience a different extent of anisotropic effect exerted by the neighboring benzene ring.
- 英文摘要: --
- 中文關鍵字: Dimethyl sulfoxide; Solvent effect; Nuclear magnetic resonance; Phenyl vinyl ketone.
- 英文關鍵字: --