- 作者: Chi-Yuan Chen; Shih-Hwa Chiou; Chih-Yang Huang; Chia-Ing Jan; Shu-Chun Lin; Ming-Long Tsai; Jeng-Fan Lo
- 作者服務機構: Institute of Oral Biology, National Yang Ming University, Taipei, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
The progression and metastasis of solid tumors, including head and neck squamous cell
carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer
stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from
primary tumors using three sequential rounds of xenotransplantation. SASVO3 possesses
enhanced tumorigenic ability both in vitro and in vivo. Moreover, SASVO3 exhibits
properties of cancer stem cells, including that increased the abilities of sphere-forming, the
number of side population cells, the potential of transplanted tumor growth and elevated
expression of the stem cell marker Bmi1. Injection of SASVO3 into the tail vein of nude
mice resulted in lung metastases. These results are consistent with the postulate that the
malignant and/or metastasis potential of HNSCC cells may reside in a stem-like
subpopulation. - 中文關鍵字: --
- 英文關鍵字: --