• 作者： 陳森輝; 林國信; 陳?霖
• 作者服務機構： 國立臺灣大學醫學院小兒科
• 中文摘要： 檢查49例紅血球G-6-PD缺乏純合子(homozygotes)及16例雜合子(heterozygotes)病例和19位正常國人白血球G-6-PD活性，我們發現紅血球G-6-PD缺乏新生兒(9.2±5.4IU/10 WBC）與小孩（11.2±5.3 IU/10 WBC）顯然比正常人(22.9±5.1 IU/10 WBC P> 0.01）為低，70％的紅血球G-6-PD缺乏新生兒及58％G-6-PD缺乏小孩之白血球G-6-PD活性在13 IU/10 WBC以下。 16例紅血球G-6-PD缺乏母親之白血球酵素（14.6±8.6IU/109 WBC）亦比正常者為低（P<0.01）。 本研究發現，國人紅血球G-6-PD缺乏病例之白血球酵素活性亦有缺乏現象，然沒有一病例有反覆感染之情形。
• 英文摘要： The activity of glucose-6-phosphate dehydrogenase (G-6-PD) in leucocytes was studied for erythro-cyte G-6-PD deficiency using 49 hemizygous males, 16 heterozygous females, and 19 normal controls. The mean G-6-PD activity in leucocytes of the affected neonates (9.2±5.4 units) and the children(11.2±5.3 units) were significantly lower than those of normal newborns（22.9±5.1 units, P＜0.01）.Seventy percent of the effected newborns and 58% of the children with G-6-PD deficiency had the leuco-cyte enzyme activity of less than 13 IU/10 WBC. The leucocyte enzyme activity（14.6±8.6 units) of 16 heterozygous G-6-PD deficient mothers wasalso lower than that of normal controls（23.1±7.0 units). The present study thus concludes that, in G-6-PD deficient Chinese, the enzyme defect is demon-strable not only in erythrocytes but also in leucocytes.
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