- 作者: Henriette Walter Katrin Ramskogler Brigitte Semler Otto Michael Lesch Werner Platz
- 作者服務機構: Department of Psychiatry. University of Vienna, and Anton Proksch Institute, Vienna, Austria, Bonhoeffer Clinic, Berlin, Germany
- 中文摘要: --
- 英文摘要: A considerable number of animalstudies on the effectsof dopaminergic agents on alcohol intake behavior havebeen performed. Acute alcohol administration in ratsinduces dopamine release in the caudate nucleus and inthe nucleus accumbens, an effect related among othersto reinforcement. It has been repeatedly suggested thatD and D receptor activation mediates reward. As alco-hol consumption and dopaminergic transmission seemto have a close relationship, all kinds of dopaminergicagents may be regarded as putative therapeutics for pre-venting relapse. In a prospective European double-blindmulticenter clinical trial,comparing the D , D , D antag-onist flupenthixol and placebo in 281 chronic alcohol-dependent patients (27.4% women) , the application ofthe Lesch typology made an outcome differentiationpossible. It could be shown in which patients flupenthix-of administration was followed by a significantly higherrelapse rate and in which patient groups no differenceswere found when compared to placebo.
- 中文關鍵字: --
- 英文關鍵字: Alcohol. Relapse. Dopamine. Lesch tpology. Flupenthixol