• 作者： 何師竹; 吳香達; 胡小婷; 劉武?
• 作者服務機構： 榮民總醫院婦產部; 國立陽明醫院微生物學科﹑醫事技術系
• 中文摘要： 本研究欲藉病毒之分離，鑑定及血清中和抗體效價之測定，探求單純庖疹病毒第二型與子宮
  頸癌之關係。選取子宮頸癌、其他癌症、子宮頸陰道炎及健康對照組四組女性受檢者為研究對象
  。鑑定病毒的方法包括間接免疫螢光試驗、免疫連?法，同時觀察病毒在各種培養細胞中生長
  情況。280位受檢者有17例分離出單純庖疹病毒（6.0%），其中兩例為第一型病毒（佔總數之
  11.76%），餘皆為第二型病毒。由各病毒株在不同組織培養細胞中敏感性的差異來判斷，子宮
  頸癌組與炎症組所分離之病毒有生物學上之差異。子宮頸癌組之病毒分離率及由血清中兩型病毒
  抗體指數測定之第二型病毒發生率皆與其他各組無所差別。但發現有二病例之第二型病毒之中和
  抗體效價於治療後癌病復發時上升，且與社會經濟狀況、性交對象多寡以及其他性病之感染似有
  相關性。
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• 英文摘要： This study has been done in an attemptto re-evaluate the correlation of herpes sim-plex virus type 2 infection and cancer ofuterine cervix. Four groups of patients：(A)cervical carcinoma, (B) other malignancy, (C) cervicovaginitis and (D) healthy controlwith age matched to A group were set·Indirect immunofluorescent antibody technique, enzyme-linked immunoassay were used foridentification of the virus isolated from theclinical specimens. Various tissue culturecells were used to characterize the virusstrains. A slight biological difference asdemonstrated by host ranges were seen invirus strains from group A and group C. HSV were isolated from 17 out of 280cases (6.07%). Among them 2 cases weretype 1, the others were all type 2. Therewas no statistically significant data inthis study to support the hypothesis of thecorrelation of HSV-2 infection and the ocur-rence of cervical cancer from rate of virusisolation, serum neutralizing antibody index.However, increased neutralizing antibodytiter was seen in patiets with recurrentcancer. Increased titer seems also correlatedwith social ecnomic condition, sexual behaviorand other sexual-transmitted parasitic infec-tion.
• 中文關鍵字： --
• 英文關鍵字： --