• 作者： 張傳?; 董倫賢; 陳瑞龍; 張玉珍;
• 中文摘要： 1. 於腹腔注射 Uncarine A 400 mg/kg 時，則四隻小鼠中有二隻在 24 小時內死亡，劑量若小於200 mg/kg，則對小鼠的行為沒有顯著的影響。 2. Uncarine A（10-40 mg/kg, i. p.）對 Grollman 腎性高血壓之大鼠具降壓作用，在 17～21小時開始顯著降低血壓，於24～28小時之作用時間後才恢復，並且呈劑量依賴性。UncarineB 則不起作用。但 Uncarine A 和Uncarine B 對正常血壓之大鼠，除靜脈注射時有短暫性降壓作用外，均無降壓作用。 3. Uncarine A 和 Uncarine B 對 Pithed rats 之交感神經刺激之昇壓反應均無作用。 4. Uncarine A 和 Uncarine B 在麻醉的貓僅生短暫之心跳加快及血壓下降，Propranolol5 mg/kg 祗能抑制 Uncarine A 短暫之心跳加快，Uncarine A 10 mg/kg 可輕微抑制頸動脈阻塞之昇壓反射約 40%，但對交感神經刺激之瞬膜收縮，Norepinephrine（NE）及 Isoprenaline均無加強作用。 5. Uncarine A 和 Uncarine B 並不降低大鼠心臟之 NE 含量，而 Uncarine A 20 mg/kg似可加強 reserpine 在心臟對 NE 之抽空作用。 6. Uncarine A 減低大鼠之探索行為，並使其活動性降低，亦抑制小鼠之活動性，並使其呼吸頻率增加。 7. Uncarine A 在 24 小時內對大鼠之排尿有顯著之抑制。 8. Uncarine A 和 Uncarine B 在天竺鼠之離體心房可抑制自發性額外收縮和 Ouabain 不整脈，對心房交感神經之刺激則不起作用。在活體天竺鼠，Uncarine 可抑制對 Ouabain 引起之不整脈，但在鴿子卻不改變對 Ouabain 之致死量。 9. Uncarine A 可加強 Metrazol seizure 及 Electroshock。 10. Uncarine A 之降壓作用可能抑制血管運動中樞。由於對高血壓之動物才有作用，也很可能作用於高血壓動物之平滑肌上，使血管平滑肌放鬆。
• 英文摘要： 1. Uncarine A was lethal to mice at 400 mg/ kg, (i. p.). At doses lower than 200 mg/kg, uncarine A has no apparent effect on the behavior of mice.2. Uncarine A (10-40 mg/kg, i. p.) decreased the systolic blood pressure in Grollman renal hypertensive rats measured by indirect me- thod. The hypotensive action of uncarine A emerged 17-21 hrs after treatment, per- sisted for 24-28 hrs and was dose dependent. Uncarine B has no effect on these hyper- tensive rats. In normotensive rats, however no hypotensive action could be observed with either uncarine A or B.3. The pressor response in pithed rat to lumbar sympathetic stimulation was not depressed by uncarines.4. Both uncarines in anaesthetized cats pro- duced transient tachycardia and hypotension, only the tachycardia was antagonized by propranolol. Uncarine A (10 mg/kg, i. v.) also depressed the pressor effect induced by carotid occlusion by about 40%, whereas the response of nictitating membrane to preganglionic stimulation was not decreased. Neither effect on the response to norepine- phrine and isoprenaline was observed.5. Uncarine A and B did not lower the cardiac NE content of rat but uncarine A (20 mg/ kg, i. p.) seems to enhance the NE depletion by reserpine.6. Uncarine A decreased the exploratory behavior of rats. In mice, uncarine A decreased the motor activity but increased the rate of respiration.7. Urine formation in rats was inhibited by uncarine A.8. Both uncarine A and B suppressed spontane- ous extrasystoles and ouabain-induced ar- rhythmia in isolated guinea-pig atria, but had no effect on the auricular sympathetic stimulation. In vivo, uncarine A antago- nized the ouabain-induced arrhythmia in guinea-pigs, but did not alter the lethal doses of ouabain in pigeons.9. Uncarine A appeared to enhance the metrazol- seizure and electroshock.10. It is inferred that uncarine A may first inhibit vasomotor center then exert its hypo- tensive action. Owing to its specificity to hypertensive rats, uncarine A may also alter thehypertensive vascular smooth muscle to respond normally.
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