- 作者: Shawkat A. Abdel-Mohsen
- 作者服務機構: Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516, Egypt
- 中文摘要: 5-(2-Aminothiazol-4-yl)-8-hydroxyquinoline 2 has been synthesized by treating thiourea with 5-chloroacetyl-8-hydroxyquinoline 1. The amine 2 was treated with aromatic aldehydes to furnish schiff bases 6a-c which on treatment with phenyl isothiocyanate gave the corresponding thiazolo-s-triazines 7a-c. Reaction of 2 with phenyl isothiocyanate gave the corresponding aminocarbothiamide derivative 8 which on reaction with malonic acid in acetyl chloride afforded thiobarbituric acid derivative 9. Coupling of 9 with diazonium salt gave the phenyl hydrazono derivative 10. However, reaction of 2 with carbon disulphide and methyl iodide afforded dithiocarbamidate 12 which on treatment with ethylenediamine, o-aminophenol and/or phenylenediamine gave the aminoazolo derivatives 13-15, respectively. Other substituted fused thiazolopyrimidines 16-20 have been also prepared by the reaction of 2 with some selected dicarbonyl reagents. The characterisation of synthesized compounds has been done on the basis of elemental analysis, IR, 1H-NMR and mass spectral data. All the newly synthesized compounds have been screened for their antimicrobial activities.
- 英文摘要: --
- 中文關鍵字: 1,3-Thiazolo-8-quinolinol; ?Thiazolo[3,2-a]triazine; ?Thiazolylaminobenzazoles; ?Thiazolo[3,2-a]pyrimidines antimicrobial activity.
- 英文關鍵字: --