- 作者: Fang-Chia Chang; Huei-Yann Tsai; Ming-Chien Yu; Pei-Lu Yi; Jaung-Geng Lin
- 作者服務機構: Neuroscience Laboratory, Department of Neurology, and Department of Chinese-Western Cooperative Treatment, China Medical Universtiy Hospital, Taichung; Depatrment of Pharmacology, and Acupuncture Research Center and Institute of Chinese Medical Science, China Medical University, Taichung, and Department of Nursing, Jen-Te Junior College of Meducine, Nursing and Management Miaoli, Taiwan/ROC
- 中文摘要: --
- 英文摘要: Evidence in the past decade indicates that the mecha-nisms of anti-nociception of electroacupuncture(EAc)involve actions of neuropeptides(i.e.,enkephalin andendorphin)and monoamines(i.e., serotonin and norepi-nephrine)in the central nervous system. Our presentresults using a subcutaneous injection of formalin to testpain sensation in mice provide further understanding ofthe involvement of serotonin in the actions of EAc-induced analgesia.Our observations show that(1)EAc atthree different frequencies(2,10 and 100 Hz)elicited ananti-nociceptive effect as determined by behavioral ob-servations of reduced hindpaw licking;(2)exogenouslyintracerebroventricular administration of 5-hydroxy-tryptamine(5-HT) exhibited an analgesic effect, whichpartially mimicked the analgesic actions of EAc;(3) theanti-nociception of EAc at different frequencies was at-tenuated after reduced biosynthesis of serotonin by theadministration of the tryptophan hydroxylase inhibitor,p-chlorophenylalanine, and(4)the 5-HT1A and 5-HT3receptor antagonists, pindobind-5-HTlA and LY-278584,respectively, blocked three different frequencies of EAc-induced analgesic effects, but the anti-nociceptive effectof 100 Hz EAc was potentiated by the 5-HT2 receptorantagonist, ketanserin.These observations suggest that5-HT1A and 5-HT3 receptors partially mediate theanalgesic effects of EAc, but that the 5-HT2 receptor isconversely involved in the nociceptive response.
- 中文關鍵字: --
- 英文關鍵字: --