- 作者: Mieczystaw Pokorski; Ahlam Ramadan; Magdalena Marczak
- 作者服務機構: Department of Respiratory Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
- 中文摘要: --
- 英文摘要: The redox signaling is germane for the hypoxia-sensingmechanisms at the carotid body. This raises the strongpossibility that agents possess reducing and antioxidantattributes, such as ascorbate, could influence the hyp-oxic respiratory response. However, water solubility ofascorbate makes its effectiveness at membrane-associ-ated target sites dubious. In this study, we sought todetermine the effect of ascorbyl-6-palmitate (AP), a lipid-soluble derivative of ascorbate which penetrates bio-membranes, on hypoxic respiration in the anesthetized,paralyzed and ventilated cat. AP was given by gavage:600 mg/kg daily for 6 days before the beginning of theacute experiment. Respiration was then assessed fromthe phrenic electroneurogram, from which peak phrenicamplitude, a surrogate of tidal component, respiratoryfrequency, and their product, the minute phrenic output,were quantified. The response to normocapnic hypoxia,7% O in N , in the AP-treated cats was compared withthat in controls. We found that AP augmented hypoxicrespiration, delayed the appearance of hypoxic depres-sion and decreased it, although the stimulatory/depres-sant character was preserved. The results suggest thatthe ascorbate moiety of AP interacts with the hypoxia-sensing mechanisms. Ascorbate may affect hypoxic res-piration at multiple stages of chemotransduction path-ways, which are subject to continuing uncertainties. Thestudy highlights the augmentative effect of AP, a redoxmodulator, on hypoxic respiration, which may have atherapeutic potential.
- 中文關鍵字: --
- 英文關鍵字: --