- 作者: Ran Luo, Xiongwei Wang, Yuanxun Dong, Lei Wang and Chunlei Tian
- 中文摘要: --
- 英文摘要:
Background:
The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells.
Results:
The results showed that U87 cells and human glioma tissue expressed PAR2. Exposure to tryptase, or the PAR2 active peptide, increased STAT3 phosphorylation in the radiated U87 cells, reduced U87 cell apoptosis, suppressed the expression of p53 in U87 cells.
Conclusions:
Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. The results implicate that PAR2 may be a novel therapeutic target in the treatment of glioma. - 中文關鍵字: --
- 英文關鍵字: Glioma, Tryptase, Protease-activated receptor 2, Signal transducer and activator of transcription 3, p53