- 作者: 黃萬出; 蓋博納瓦
- 作者服務機構: 國防醫學院生理及生物物理學科; 美國阿拉巴馬大學腎臟學研究與訓練中心
- 中文摘要:
本實驗旨在探討乙型血管張力素在腎小管腎絲球?饋機制中所扮演之調節作用的角色。實驗時之腎小管腎絲球?饋
反應是於大白鼠在對照情況、給予血管張力素轉化?抑制劑及給予轉化?抑制劑外並加乙型血管張力素等三種情況下,
藉逐步增加近側腎小管末段灌流量時所量得之近側腎小管初段停流壓反應而加以評估,並以未灌流時之停流壓估測腎絲
球微血管血壓。結果顯示在給予血管張力素轉化?抑制劑後,大白鼠平均動脈壓由124±3降至106±3毫米汞柱,而腎絲
球壓由53±1.4降至49±0.8毫米汞柱,此時停流壓?饋反應幅度顯著降低,由11.0±1.3減為2.7±0.6毫米汞柱。若在
給予轉化?抑制之同時再外加乙型血管張力素則使?饋反應恢復而趨近正常。這些結果顯示轉化?抑制劑經由減弱腎小
管腎絲球?饋機制而降低血管張力素對腎臟的作用。n - 英文摘要: To examine the modulatory role of angiotensin II on the tubuloglomerular feedback (TGF) me-chanism, TGF responses were assessed during control conditions, converting enzyme inhibiton (CEI;MK 422, 0.6 mg/kg-hr) and during continued CEI with the replacement of angiotensin II. TGF responseswere assessed from stop flow pressure (SFP) feedback responses obtained during step increases in the lateproximal perfusion rate from 0-40 nl/min. SFP values in the absence of perfusion were used to estimateglomerular pressure (GP) under conditions where the influence of the TGF mechanism should be at aminimum. During CEI, the arterial pressure decreassed from 124±3 to 106±3 mmHg and the estimatedGP decreased from 531±1.4 to 49±0.8 mmHg. There was a marked attenuation in the magnitude of SFPfeedback responses from 11.0±1.3 to 2.7±0.6 mmHg. TGF feedback responses, however, were restoredtowards normal during superimposed angiotensin II infusion (7.7±0.9 mmHg). These results indicate thatconverting enzyme inhibition decreases the effects of angiotensin II on the kidney through TGF dependentmechanism.
- 中文關鍵字: angiotensin II; tubuloglomerular feedback; angiotensin converting enzyme inhibitor; enalaprilat
- 英文關鍵字: --